| Episode # |
Original Air Date |
Guests |
| |
| Season 1 |
| |
| 1. | 1-1 | 02 Jun 02 | Jimmy Kimmel & Wanda Sykes (22 min) |
| 2. | 1-2 | 09 Jun 02 | Denis Leary & Sarah Silverman (22 min) |
| 3. | 1-3 | 16 Jun 02 | Wu Tang Clan (22 min) |
| 4. | 1-4 | 23 Jun 02 | Jimmy Kimmel & Wanda Sykes (22 min) |
| 5. | 1-5 | 30 Jun 02 | David Alan Grier & Dave Attell (22 min) |
| 6. | 1-6 | 07 Jul 02 | Susie Essman & Jim Florentine (22 min) |
| 7. | 1-7 | 14 Jul 02 | Sarah Silverman & Tracy Morgan (22 min) |
| 8. | 1-8 | 21 Jul 02 | Kevin Nealon & Super Dave Osborne (22 min) |
| 9. | 1-9 | 28 Jul 02 | Jimmy Kimmel & Adam Carolla (22 min) |
| 10. | 1-10 | 04 Aug 02 | Dane Cook & Sarah Silverman (22 min) |
| |
| Season 2 |
| |
| 11. | 2-1 | 04 Mar 03 | Jimmy Kimmel & Sarah Silverman (22 min) |
| 12. | 2-2 | 11 Mar 03 | Wanda Sykes & Robert Schimmel (22 min) |
| 13. | 2-3 | 18 Mar 03 | Snoop Dogg & Kevin Nealon (22 min) |
| 14. | 2-4 | 25 Mar 03 | Jeff Garlin & Gilbert Gottfried (22 min) |
| 15. | 2-5 | 01 Apr 03 | Fred Armisen & Kevin Nealon (22 min) |
| 16. | 2-6 | 08 Apr 03 | Wanda Sykes & Bobcat Goldthwait (22 min) |
| 17. | 2-7 | 15 Apr 03 | Adam Carolla & Jim Florentine (22 min) |
| 18. | 2-8 | 22 Apr 03 | Adam Carolla & Dr. Drew Pinsky (22 min) |
| 19. | 2-9 | 29 Apr 03 | Jimmy Kimmel & David Alan Grier (22 min) |
| 20. | 2-10 | 06 May 03 | Fred Armisen & Sarah Silverman (22 min) |
| 21. | 2-11 | 16 Sep 03 | Jimmy Kimmel & Fred Armisen (22 min) |
| 22. | 2-12 | 23 Sep 03 | Wanda Sykes & Kevin Nealon (22 min) |
| 23. | 2-13 | 30 Sep 03 | Adam Carolla & Kevin Kimmel (22 min) |
| 24. | 2-14 | 07 Oct 03 | Jimmy Kimmel & Gilbert Gottfried (22 min) |
| 25. | 2-15 | 14 Oct 03 | David Alan Grier & Super Dave Osborne (22 min) |
| 26. | 2-16 | 21 Oct 03 | Robert Smigel & Adam Carolla (22 min) |
| 27. | 2-17 | 28 Oct 03 | David Alan Grier & Jeff Garlin (22 min) |
| 28. | 2-18 | 04 Nov 03 | Jimmy Kimmel & Adam Carolla (22 min) |
| 29. | 2-19 | 11 Nov 03 | Bob Odenkirk & Fred Armisen (22 min) |
| 30. | 2-20 | 18 Nov 03 | Jim Florentine & Kathy Griffin (22 min) |
| 31. | 2-21 | 10 Feb 04 | Eminem & Sarah Silverman (22 min) |
| 32. | 2-22 | 17 Feb 04 | Kevin Nealon & Wanda Sykes (22 min) |
| 33. | 2-23 | 24 Feb 04 | Jamie Kennedy & David Alan Grier (22 min) |
| 34. | 2-24 | 02 Mar 04 | Wanda Sykes & Kevin Nealon (22 min) |
| 35. | 2-25 | 09 Mar 04 | Adam Carolla & David Alan Grier (22 min) |
| 36. | 2-26 | 16 Mar 04 | Eminem & Jeff Goldblum (22 min) |
| 37. | 2-27 | 23 Mar 04 | Seth Green & Jamie Kennedy (22 min) |
| 38. | 2-28 | 30 Mar 04 | Wanda Sykes & Adam Carolla (22 min) |
| 39. | 2-29 | 06 Apr 04 | Kevin Nealon & Sarah Silverman (22 min) |
| 40. | 2-30 | 13 Apr 04 | Jimmy Kimmel & Fred Armisen (22 min) |
| |
| Season 3 |
| |
| 41. | 3-1 | 20 Jul 04 | Ludacris & Drew Carey (22 min) |
| 42. | 3-2 | 27 Jul 04 | Tracy Morgan & Tony Barbieri (22 min) |
| 43. | 3-3 | 03 Aug 04 | Andy Richter & Sarah Silverman (22 min) |
| 44. | 3-4 | 10 Aug 04 | Jimmy Kimmel & Adam Carolla (22 min) |
| 45. | 3-5 | 17 Aug 04 | Jimmy Kimmel & Kevin Nealon (22 min) |
| 46. | 3-6 | 24 Aug 04 | Wanda Sykes & Kevin Nealon (22 min) |
| 47. | 3-7 | 31 Aug 04 | Bob Odenkirk & Adam Carolla (22 min) |
| 48. | 3-8 | 07 Sep 04 | Ludacris & Kevin Nealon (22 min) |
| 49. | 3-9 | 14 Sep 04 | Eminem & Tracy Morgan (22 min) |
| 50. | 3-10 | 21 Sep 04 | Jack & Sharon Osbourne (22 min) |
| 51. | 3-11 | 12 Jan 05 | Drew Carey & Jeff Goldblum (22 min) |
| 52. | 3-12 | 19 Jan 05 | Wanda Sykes & Sarah Silverman (22 min) |
| 53. | 3-13 | 26 Jan 05 | Tracy Morgan & Jimmy Kimmel (22 min) |
| 54. | 3-14 | 02 Feb 05 | Jason Schwartzman & Hank Azaria (22 min) |
| 55. | 3-15 | 09 Feb 05 | Adam Carolla & David Alan Grier (22 min) |
| 56. | 3-16 | 16 Feb 05 | Tracy Morgan & Jimmy Kimmel (22 min) |
| 57. | 3-17 | 23 Feb 05 | Wanda Sykes & Kevin Nealon (22 min) |
| 58. | 3-18 | 02 Mar 05 | Bob Odenkirk & Tracy Morgan (22 min) |
| 59. | 3-19 | 09 Mar 05 | Dane Cook & Brian Posehn (22 min) |
| |
| Season 4 |
| |
| 60. | 4-1 | 09 Feb 07 | Lil Jon & Sarah Silverman (22 min) |
| 61. | 4-2 | 16 Feb 07 | Jimmy Kimmel & Steve-O (22 min) |
| 62. | 4-3 | 23 Feb 07 | Dane Cook & Chamillionaire (22 min) |
| 63. | 4-4 | 02 Mar 07 | Good Charlotte & Lil Jon (22 min) |
| 64. | 4-5 | 09 Mar 07 | Dave Chappelle & Seth Green (22 min) |
| 65. | 4-6 | 16 Mar 07 | Andy Milonakis & Ryan Dunn (22 min) |
| 66. | 4-7 | 23 Mar 07 | Adam Carolla & Dane Cook (22 min) |
| 67. | 4-8 | 30 Mar 07 | Jimmy Kimmel & Nick Cannon (22 min) |
| |
| Season 5 |
| |
| 68. | 5-1 | 25 Sep 19 | Tracy Morgan, Adam Carolla & Aubrey Plaza |
| 69. | 5-2 | 02 Oct 19 | Jimmy Kimmel, Kathy Griffin & Jeff Ross |
| 70. | 5-3 | 09 Oct 19 | Sarah Silverman, Abbi Jacobson & Will Forte |
| 71. | 5-4 | 16 Oct 19 | Jimmy Kimmel, Tracy Morgan & David Alan Grier |
| 72. | 5-5 | 30 Oct 19 | Sarah Silverman, Tiffany Haddish & Kevin Nealon |
| 73. | 5-6 | 06 Nov 19 | David Alan Grier, Will Forte & Chelsea Peretti |
| 74. | 5-7 | 13 Nov 19 | Tiffany Haddish, Roy Wood Jr. & Thomas Lennon |
| 75. | 5-8 | 27 Nov 19 | Wanda Sykes, Nick Kroll & Tracy Morgan |
| 76. | 5-9 | 04 Dec 19 | Adam Carolla, David Koechner & Natasha Leggero |
| 77. | 5-10 | 11 Dec 19 | Bobby Brown, Wanda Sykes & Kathy Griffin |
| 78. | 5-11 | 01 Apr 20 | Jimmy Kimmel, Sarah Silverman & Nikki Glaser |
| 79. | 5-12 | 08 Apr 20 | Aubrey Plaza, Ron Funches & Derek Waters |
| 80. | 5-13 | 15 Apr 20 | Tracy Morgan, Kevin Nealon & Adam Carolla |
| 81. | 5-14 | 22 Apr 20 | Chelsea Peretti, Derek Waters & Aubrey Plaza |
| 82. | 5-15 | 29 Apr 20 | Jeff Ross, Tracy Morgan & Roy Wood Jr. |
| 83. | 5-16 | 06 May 20 | Wanda Sykes, David Alan Grier & Abbi Jacobson |
| 84. | 5-17 | 13 May 20 | Kevin Nealon, Jimmy Kimmel & Paul Scheer |
| 85. | 5-18 | 20 May 20 | Brian Posehn, Nick Kroll & David Alan Grier |
| 86. | 5-19 | 27 May 20 | Brian Posehn, Demetri Martin & Adam Carolla |
| 87. | 5-20 | 03 Jun 20 | Nikki Glaser, Jimmy Kimmel & Tracy Morgan |
| |
| Season 6 |
| |
| 88. | 6-1 | 05 May 21 | Jimmy Kimmel, Annie Murphy & Iliza Shlesinger |
| 89. | 6-2 | 12 May 21 | Adam Carolla, Punkie Johnson & Melissa Villasenor |
| 90. | 6-3 | 19 May 21 | Chelsea Peretti, Heidi Gardner & J.B. Smoove |
| 91. | 6-4 | 26 May 21 | Jimmy Kimmel, Wanda Sykes & Kathy Griffin |
| 92. | 6-5 | 02 Jun 21 | Bobby Brown, Natasha Leggero & Paul Scheer |
| 93. | 6-6 | 09 Jun 21 | Brian Posehn, Kevin Nealon, Quinta Brunson |
| 94. | 6-7 | 16 Jun 21 | Tiffany Haddish, Tracy Morgan & Bobby Moynihan |
| 95. | 6-8 | 23 Jun 21 | Iliza Shlesinger, Heidi Gardner & Jonathan Kimmel |
| 96. | 6-9 | 30 Jun 21 | Bobby Brown, Jimmy Kimmel & Sam Jay |
| 97. | 6-10 | 07 Jul 21 | Wanda Sykes, Adam Carolla & Annie Murphy |
| 98. | 6-11 | 06 Jul 22 | Tiffany Haddish, Desus & Mero & Jimmy Kimmel |
| 99. | 6-12 | 06 Jul 22 | Adam Carolla, Kathy Griffin & Kyle Dunnigan |
| 100. | 6-13 | 13 Jul 22 | Desus & Mero, Jimmy Kimmel & Natasha Leggero |
| 101. | 6-14 | 13 Jul 22 | Wanda Sykes, JB Smoove, Adam Carolla |
| 102. | 6-15 | 20 Jul 22 | Jimmy Kimmel, Tiffany Haddish & Ron Funches |
| 103. | 6-16 | 20 Jul 22 | Tracy Morgan, Heidi Gardner & Kevin Nealon |
| 104. | 6-17 | 27 Jul 22 | Paul Scheer, Wanda Sykes & Adam Carolla |
| 105. | 6-18 | 27 Jul 22 | Tiffany Haddish, Meg Stalter & Bobby Moynihan |
| 106. | 6-19 | 03 Aug 22 | Bobby Brown, Heidi Gardner & Jimmy Kimmel |
| 107. | 6-20 | 03 Aug 22 | Tracy Morgan, Tim & Eric & Ron Funches |
| |
| Specials |
| |
| S03. | 3-0 | 21 Dec 04 | Holiday Special (22 min) |
| S03. | 3-0 | 23 Mar 05 | Best-of Special 1 (22 min) |
| S03. | 3-0 | 30 Mar 05 | Best-of Special 2 (22 min) |
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